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34 The POUNDS Lost trial ran 811 adults through four different macronutrient patterns at a 750-Calorie-per-day deficit

(2019) 7:e14138

As shown in the study by Chang et al., anti-PD1 treatment led to the restoration of the glycolytic and cytotoxic functions of T cells to fight established cancer, suggesting that T-cell hyporesponsiveness in the TME may be due to metabolic restriction [339]